P02-013 - TH17 cells and regulatory T cells in TRAPS
نویسندگان
چکیده
Introduction The immunopathogenesis of TRAPS is thought to centre on activation of the innate immune system resulting in episodic inflammation. The adaptive immune system, Tregs and Th17 T cells, has not been studied in TRAPS. Different anti-TNF agents have different clinical effects on TRAPS i.e. etanercept has benefits but adalimumab and infliximab may trigger flares of TRAPS. It has been shown that different anti-TNF agents have differential effects on regulatory T cells in rheumatoid arthritis i.e. adalimumab but not etanercept induces peripheral Tregs which have the ability to suppress Th17 cells. We considered whether Tregs and Th17 cells in TRAPS could underpin differential response to biologicals.
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